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He developed kisspeptin antagonists as potential therapeutics in hormone-dependent diseases. More recently he has focused on novel GPCRs regulating reproduction, appetite, inflammation, cell invasion and angiogenesis with a particular focus on the RFamides such as metastin/kisspeptin and gonadotropin-inhibitory-hormone, and NKB and prokineticins.

His group's research on direct antiproliferative effects of selective GnRH analogues on tumour cells has revealed the novel concept of ligand-induced-selective-signalling by GnRH analogues (now called 'biased signalling'), which has implications for improved selectivity in the development of new GnRH therapeutics and other GPCR targets. He has participated in, and led, a number of programmes developing GnRH analogues for use in a wide range of clinical pathologies.

His laboratory delineated GnRH binding sites and the molecular mechanisms underlying receptor activation and coupling. He pioneered the discovery of the GnRH prohormone, novel GnRH structures, and the first cloning of the GnRH I and GnRH II receptors. Selected publications | Contact details | Group Membersįull Member, Institute of Infectious Disease and Molecular Medicine Department of Integrative Biomedical Sciences, Faculty of Health Sciences, UCT Professor and Director, Centre for Neuroendocrinology, University of Pretoria Research Fellow, Centre for Brain Discovery, University of Edinburgh, UK, Emeritus Professor, University of St Andrews.īob Millar's research focuses on peptide regulators of reproductive hormones.

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